Fabio Gallazzi

Fabio Gallazzi
Research Assistant Professor
Phone: 
5738829024
Office: 
LSC 471b
Research Emphasis: 

Peptides and peptidomimetics synthesis, characterization and potential use for biomedical purposes; lc-ms analyses and MS assisted preparative chromatographic purification

Education: 

1993     University of Milan Degree in Chemistry (corresponding to a U.S. Master’s degree)

1996     University of Milan Postgraduate Diploma in Biotechnological Applications (corresponds to a U.S. PhD)

Professional Experience: 

2005-Current      University of Missouri Assistant Research Professor and Co-Director of the Molecular Interactions Core (previously named Structural Biology Core)

2002-2005         University of Missouri Research Associate position with the responsibility of a peptide core.

2000-2002         University of Missouri Post Doctorate contract for the establishment of a solid phase synthesis facility

1998-2000         Imi Tami (ICL) Post doctoral contract for the operative responsibility of the multiple automated SPPS in a major Israeli company   

1996-1997         Hoffmann La Roche Post Doctoral Contract for the operative responsibility of a peptide synthesis laboratory fully integrated in the biomedical research centre in Milan, Italy

Research: 

My research expertise and interests deal with design, preparation, characterization and optimization of peptides and peptidomimetics modified from the natural sequence in order to meet their biomedical expectations. The number and variety of biomolecules I have synthesized and characterized allow me to play a pivotal role in multiple research projects.  My contributions are reflected in a wide variety of published works as seen in the selected list below:

Select Publications: 

Garcia, Maria Fernanda; Gallazzi, Fabio; Junqueira, Mara de Souza; Fernandez, Marcelo; Camacho, Ximena; Mororo, Janio da Silva; Faria, Daniele; Carneiro, Camila de Godoi; Couto, Marcos; Carrion, Federico; Pritsch, Otto; Chammas, Roger; Quinn, Thomas; Cabral, Pablo; Cerecetto, Hugo, Synthesis of hydrophilic HYNIC-[1,2,4,5]tetrazine conjugates and their use in antibody pretargeting with 99mTc Organic & Biomolecular Chemistry (2018), 16(29), 5275-5285

Zhang, Rui; Morton, Logan D.; Smith, Josiah D.; Gallazzi, Fabio; White, Tommi A.; Ulery, Bret D. Instructive Design of Triblock Peptide Amphiphiles for Structurally Complex Micelle Fabrication ACS Biomaterials Science & Engineering (2018), 4(7), 2330-2339

Chen, Feng; Zhang, Xiuli; Ma, Kai; Madajewski, Brian; Benezra, Miriam; Zhang, Li; Phillips, Evan; Turker, Melik Z.; Gallazzi, Fabio; Penate-Medina, Oula; Overholtzer, Michael; Pauliah, Mohan; Gonen, Mithat; Zanzonico, Pat; Wiesner, Ulrich; Bradbury, Michelle S.; Quinn, Thomas P. Melanocortin-1 Receptor-Targeting Ultrasmall Silica Nanoparticles for Dual-Modality Human Melanoma Imaging. ACS Applied Materials & Interfaces (2018), 10(5), 4379-4393

Feng, Yutian; Phelps, Tim E.; Carroll, Valerie; Gallazzi, Fabio; Sieckman, Gary; Hoffman, Timothy J.; Barnes, Charles L.; Ketring, Alan R.; Hennkens, Heather M.; Jurisson, Silvia S. Chemistry and radiochemistry of As, Re and Rh isotopes relevant to radiopharmaceutical applications: high specific activity radionuclides for imaging and treatment. Dalton Transactions (2017), 46(42), 14677-14690

Matin, Tina R.; Sigdel, Krishna P.; Utjesanovic, Milica; Marsh, Brendan P.; Gallazzi, Fabio; Smith, Virginia F.; Kosztin, Ioan; King, Gavin M. Single-Molecule Peptide-Lipid Affinity Assay Reveals Interplay between Solution Structure and Partitioning. Langmuir (2017), 33(16), 4057-4065

Radford, Lauren; Gallazzi, Fabio; Watkinson, Lisa; Carmack, Terry; Berendzen, Ashley; Lewis, Michael R.; Jurisson, Silvia S.; Papagiannopoulou, Dionysia; Hennkens, Heather M. Synthesis and evaluation of a 99mTc tricarbonyl-labeled somatostatin receptor-targeting antagonist peptide for imaging of neuroendocrine tumors. Nuclear Medicine and Biology (2017), 47, 4-9

Li, Yawen; Ma, Lixin; Gaddam, Vikram; Gallazzi, Fabio; Hennkens, Heather M.; Harmata, Michael; Lewis, Michael R.; Deakyne, Carol A.; Jurisson, Silvia S. Synthesis, Characterization, and In Vitro Evaluation of New 99mTc/Re(V)-Cyclized Octreotide Analogues: An Experimental and Computational Approach Inorganic Chemistry (2016), 55(3), 1124-1133.

Makris, George; Radford, Lauren; Gallazzi, Fabio; Jurisson, Silvia; Hennkens, Heather; Papagiannopoulou, Dionysia Synthesis and evaluation of fac-[99mTc/Re(CO)3]+ complexes with a new (N,S,N) bifunctional chelating agent: The first example of a fac-[Re(CO)3(N,S,N-sst2-ANT)] complex bearing a somatostatin receptor antagonist peptide From Journal of Organometallic Chemistry (2016), 805, 100-107

Kirby, Karen A.; Ong, Yee Tsuey; Hachiya, Atsuko; Laughlin, Thomas G.; Chiang, Leslie A.; Pan, Yun; Moran, Jennifer L.; Marchand, Bruno; Singh, Kamalendra; Gallazzi, Fabio; et al Structural basis of clade-specific HIV-1 neutralization by humanized anti-V3 monoclonal antibody KD-247 FASEB Journal (2015), 29(1), 70-80, 10.1096/fj.14-252262

Zhang, Xiuli; Teixeira, Vania; Porcal, Williams; Cabral, Pablo; Gambini, Juan-Pablo; Fernandez, Marcelo; Gallazzi, Fabio; Quinn, Thomas P. [99mTc(CO)3]+ and [99mTcO2]+ Radiolabeled Cyclic Melanotropin Peptides for Melanoma SPECT Imaging Current Radiopharmaceuticals (2014), 7(1), 63-74

Shen, Xiulong; Rajapakse, Anuruddha; Gallazzi, Fabio; Junnotula, Venkatraman; Fuchs-Knotts, Tarra; Glaser, Rainer; Gates, Kent S. Isotopic Labeling Experiments That Elucidate the Mechanism of DNA Strand Cleavage by the Hypoxia-Selective Antitumor Agent 1,2,4-Benzotriazine 1,4-Di-N-oxide Chemical Research in Toxicology (2014), 27(1), 111-118

Guo, Haixun; Gallazzi, Fabio; Miao, Yubin Design and Evaluation of New Tc-99m-Labeled Lactam Bridge-Cyclized Alpha-MSH Peptides for Melanoma Imaging Molecular Pharmaceutics (2013), 10(4), 1400-1408.

| Abd-Elgaliel, Wael R.; Gallazzi, Fabio; Garrison, Jered C.; Rold, Tammy L.; Sieckman, Gary L.; Figueroa, Said Daibes; Hoffman, Timothy J.; Lever, Susan Z. Design, Synthesis, and Biological Evaluation of an Antagonist-Bombesin Analogue as Targeting Vector. Bioconjugate Chemistry (2008), 19(10), 2040-2048.

Wei, Lihui; Butcher, Clayton; Miao, Yubin; Gallazzi, Fabio; Quinn, Thomas P.; Welch, Michael J.; Lewis, Jason S. Synthesis and biologic evaluation of 64Cu-labeled rhenium-cyclized  -MSH peptide analog using a cross-bridged cyclam chelator. Journal of Nuclear Medicine (2007), 48(1), 64-72.

Quinn, Thomas P.; Yubin, Miao; Gallazzi, Fabio. Melanocyte stimulating hormone peptides delivered to melanoma cell nuclei for cancer imaging or therapy. PCT Int. Appl. (2005), 87 pp. Gallazzi, Fabio; Wang, Yi; Jia, Fang; Shenoy, Nalini; Landon, Linda A.; Hannink, Mark; Lever, Susan Z.; Lewis, Michael R. Synthesis of Radiometal-Labeled and Fluorescent Cell-Permeating Peptide-PNA Conjugates for Targeting the bcl-2 Proto-oncogene. Bioconjugate Chemistry (2003), 14(6), 1083-1095.

Research Division: