Nanopore stochastic sensing has attracted substanital interest as a label-free technique to measure single molecules by taking advantage of the ionic current modulations produced by the movement of target analytes in a single nano-scale sized pore. A major bottleneck of utilizing nanopore sensors for practical applications is the rapid transport of target analytes through the pore since current recording techniques do not always accurately detect these rapid events. Guan's research efforts advance nanopore technology as a versatile tool for exploring various new applications, especially in medical diagnosis, homeland security, pharmaceutical screening, and environmental monitoring.